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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

Hiroyuki Inuzuka , Wenyi Wei

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major...

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