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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases

Matthew Jenner

This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the...

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