Xiaojing(John) Zhang is an Associate Professor in the Department of Biomedical Engineering at the University of Texas of Austin (UT Austin). He received his Ph.D. from Stanford University, California, and was a Research Scientist at Massachusetts Institute of Technology (MIT) before joining the faculty at UT Austin. Dr. Zhang’s research focuses on integrating Micro-electro-mechanical Systems (MEMS), nano-materials, micro-imaging and biosensors to provide innovative solutions to critical healthcare issues. Dr. Zhang has actively engaged in teaching new concepts and methods in these emerging biomedical engineering frontiers and has demonstrated innovation and excellence in engineering education. The materials presented in this textbook are based on his lecture notes while teaching a popular course on molecular sensors and nanodevices at UT Austin for the past 8 years. He has a track record for developing both core and emerging engineering curriculum along with developing well-funded research programs with fellow students. Among his numerous awards, Dr. Zhang received the Wallace H. Coulter Foundation Early Career Award in Biomedical Engineering, NSF CAREER award, DARPA Young Faculty Award among many others. To recognize his accomplishment in research and education, Dr. Zhang was selected to attend the prestigious US National Academy of Engineering, Frontiers of Engineering (NAE FOE) program in 2011, the NAE Frontiers of Engineering Education (NAE FOEE) program in 2012, and subsequently China-America Frontiers of Engineering Symposium (CAFOE) program in 2013. As an active member in his professional community, Dr. Zhang has served on numerous international conference organizing committees and editorial boards. He is an editor for ASME/IEEE Journal of Microelectromechanical Systems (JMEMS) and an associate editor Biomedical Microdevices.